PNC-28
✓ Third-party tested by certified labs
✓ Published certificates of analysis
✓ ≥98.5% purity standard
Description
Synthetic p53-penetratin peptide analog for HDM-2 binding research and pancreatic cancer cell membrane interaction studies.
Product Description
PNC-28 is a synthetic 27-amino-acid chimeric peptide containing a shorter HDM-2 binding domain derived from p53 tumor suppressor protein (residues 17-26) fused to the same cell-penetrating peptide (CPP) sequence used in PNC-27. This membrane-active peptide represents a truncated analog that lacks the first five amino acids of PNC-27’s p53 domain while retaining selective cytotoxic activity against cancer cells.
Research investigations have examined PNC-28 in studies of HDM-2/p53 protein interactions, pancreatic cancer cell necrosis mechanisms, transmembrane pore formation, and penetratin-mediated cell entry pathways. The compound is used in controlled laboratory environments for investigating anticancer peptide structure-activity relationships, membrane disruption mechanisms, and selective tumor cell targeting in various cancer cell lines including pancreatic, ovarian, and breast cancer models.
Supplied as pharmaceutical-grade lyophilized powder with third-party verified purity testing for qualified research institutions conducting in vitro research applications only.
Our Product Quality Guarantee
Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.
Buy PNC-28 Peptide From Limitless Biotech
Limitless Biotech provides USA-manufactured PNC-28 peptide for sale with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.
Specification
| Specification | Details |
|---|---|
| Sequence | Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly (27 amino acids) |
| Molecular Formula | C164H255N47O37S |
| Molecular Weight | 3509.13 |
| CAS Number | 392661-17-5 |
| Synonyms | PNC28, PNC 28, p53 17-26 penetratin peptide |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in sterile water, can be further diluted in aqueous solutions |
| Storage Conditions | Store lyophilized at -20°C; reconstituted: 4°C for 2–7 days, -20°C for long-term storage |
| Physical Appearance | White lyophilized powder |
| Shelf Life | 36 months from date of manufacture when stored properly |
| Quality Verification | Third-party tested by certified laboratory |
| Manufacturing Standard | USA-made, pharmaceutical-grade, GMP compliant |
| Intended Application | In vitro research applications only |
