Description
PNC-28 is a synthetic peptide derived from the p53 tumor suppressor protein and studied in laboratory cancer cell research. Limitless Life Nootropics offers it as a 5mg vial, made in the USA and independently tested.
What Is PNC-28?
The peptide combines two parts: residues 17-26 of p53, the region that binds the regulatory protein HDM-2 (MDM-2), and a membrane-penetrating sequence derived from the Antennapedia homeodomain. It is a shorter analog of PNC-27 and was developed by researchers at SUNY Downstate Medical Center.
In vitro studies have reported that the peptide interacts with HDM-2 expressed on the membranes of cancer cells, leading to membrane pore formation and cell necrosis, while normal cells that lack membrane HDM-2 were largely unaffected. Most published work has focused on pancreatic and other cancer cell lines.
Each Premium lyophilized vial contains 5mg and is intended solely for in-vitro laboratory investigation.
Areas of Scientific Investigation
Laboratory studies have explored this peptide across several areas of investigation:
- HDM-2 binding and membrane interaction
- Pancreatic cancer cell line studies
- Membrane pore formation assays
- Selectivity comparisons with normal cells
- Structure–activity comparisons with PNC-27
Researchers can review peer-reviewed studies on PNC-28 through the National Library of Medicine (PubMed) database.
PNC-28 Specifications
| Product | PNC-28 |
|---|---|
| Compound type | Chimeric p53/penetratin peptide |
| Format | Lyophilized (freeze-dried) powder in a sealed glass vial |
| Purity | ≥99% (HPLC verified) |
| Origin | Manufactured in the USA |
| Testing | Independent third-party lab |
| Intended use | Laboratory research only |
The Limitless Life Nootropics Standard
Limitless Life Nootropics was built around a simple idea: research results are only as reliable as the materials behind them. We focus on a carefully curated catalog of peptides and research compounds, keep inventory fresh, and publish clear specifications for every product. Our team answers technical questions quickly, and transparent pricing means no hidden fees or minimum orders for smaller labs.
Quality and Third-Party Testing
Limitless Life Nootropics sources this peptide from U.S. facilities that follow Good Manufacturing Practice principles. Each lot is sent to an independent laboratory for purity (HPLC) and identity (mass spectrometry) testing before release, giving your team consistent, traceable material from one experiment to the next.
Storage and Handling
Unopened lyophilized this peptide remains most stable when frozen at -20°C and protected from light. After reconstitution with a suitable diluent, refrigerate at 2–8°C and avoid repeated freeze-thaw cycles.
Need supplies? Pair your order with our reconstitution solution and sterile 10 mL vials for convenient preparation.
How Ordering Works
Orders placed with Limitless Life Nootropics are processed within one to two business days and ship from the United States in discreet, protective packaging. Temperature-sensitive items are packed to limit heat exposure in transit, and every order includes tracking so your lab knows exactly when materials will arrive. Secure checkout protects your payment details at every step.
Related Research Products
Teams working with this peptide often explore FOXO4-DRI 10mg, KPV and KPV Capsules. Browse the full Cellular Longevity Research and Immune Research collections, or view every compound in our research peptide catalog at Limitless Life Nootropics.
Frequently Asked Questions
Which part of p53 does it contain?
It contains residues 17-26 of p53, the HDM-2 binding domain, fused to a cell-penetrating sequence.
What size is available?
This peptide is supplied in a 5mg vial.
Is PNC-28 for human use?
No. It is sold strictly for laboratory research. It is not intended for human or animal consumption, diagnosis or treatment.
Where can I buy PNC-28 online?
You can order it directly from Limitless Life Nootropics, a U.S. supplier of third-party tested research peptides with fast, discreet shipping.
Research Use Only
All products sold by Limitless Life Nootropics are intended strictly for in-vitro laboratory research and scientific study. This product is not a drug, food, supplement or cosmetic, has not been evaluated by the FDA, and is not for human or veterinary use. Purchase is limited to qualified researchers aged 21 and over.
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