Description
FOXO4-DRI is a synthetic peptide designed to selectively target senescent cells, making it one of the most discussed compounds in aging research. Limitless Life Nootropics offers it as a 10mg vial, made in the USA.
What Is FOXO4-DRI?
Senescent cells stop dividing but resist dying, and their accumulation with age is linked to tissue dysfunction. Researchers led by Peter de Keizer found that the protein FOXO4 helps keep these cells alive by binding p53 and holding it in the nucleus, preventing p53 from triggering apoptosis.
This peptide mimics part of FOXO4 and competes for p53 binding. It is built from D-amino acids in reverse order (a D-retro-inverso design), which preserves its shape while making it highly resistant to enzymatic breakdown. In a 2017 study published in Cell, it selectively induced apoptosis in senescent cells and restored fitness, fur density and kidney function in aged and fast-aging mice.
Each Premium lyophilized vial contains 10mg.
Key Research Areas
The scientific literature describes this peptide across several areas of investigation:
- Senolytic activity in senescent cell cultures
- FOXO4–p53 protein interaction
- Aged and progeroid mouse models
- Kidney function and tissue fitness
- Chemotherapy-induced senescence
Researchers can review peer-reviewed studies on FOXO4-DRI through the National Library of Medicine (PubMed) database.
FOXO4-DRI Specifications
| Product | FOXO4-DRI 10mg |
|---|---|
| Compound type | D-retro-inverso peptide, FOXO4–p53 antagonist |
| Format | Lyophilized (freeze-dried) powder in a sealed glass vial |
| Purity | ≥99% (HPLC verified) |
| Origin | Manufactured in the USA |
| Testing | Independent third-party lab |
| Intended use | Laboratory research only |
The Limitless Life Nootropics Standard
When a protocol depends on precise inputs, sourcing matters. Limitless Life Nootropics works only with U.S. manufacturing partners, verifies every lot with independent testing, and stores finished product under controlled conditions. The result is dependable, well-documented material that helps your team reduce variability between experiments and focus on the science.
Quality and Third-Party Testing
Consistency matters in research. That is why Limitless Life Nootropics only releases this peptide after independent third-party testing confirms purity and identity. Production takes place in the USA under strict quality controls, and lot-specific documentation supports reproducible results.
Storage and Handling
For maximum shelf life, keep this peptide in its original sealed vial in a freezer (-20°C). Reconstituted material should be refrigerated, handled with sterile technique, and never left at room temperature for extended periods.
Need supplies? Pair your order with our reconstitution solution and sterile 10 mL vials for convenient preparation.
Fast, Discreet U.S. Shipping
Orders placed with Limitless Life Nootropics are processed within one to two business days and ship from the United States in discreet, protective packaging. Temperature-sensitive items are packed to limit heat exposure in transit, and every order includes tracking so your lab knows exactly when materials will arrive. Secure checkout protects your payment details at every step.
Related Research Products
Teams working with this peptide often explore L-Glutathione (500mg), NMN Powder and PNC-28. Browse the full Cellular Longevity Research collection, or view every compound in our research peptide catalog at Limitless Life Nootropics.
Frequently Asked Questions
What does D-retro-inverso mean?
The peptide uses D-amino acids in reverse sequence, which keeps a similar shape to the natural sequence while resisting enzymatic degradation.
What size is available?
This peptide is supplied in a 10mg vial.
Is FOXO4-DRI for human use?
No. It is sold strictly for laboratory research. It is not intended for human or animal consumption, diagnosis or treatment.
Where can I buy FOXO4-DRI online?
You can order it directly from Limitless Life Nootropics, a U.S. supplier of third-party tested research peptides with fast, discreet shipping.
Research Use Only
All products sold by Limitless Life Nootropics are intended strictly for in-vitro laboratory research and scientific study. This product is not a drug, food, supplement or cosmetic, has not been evaluated by the FDA, and is not for human or veterinary use. Purchase is limited to qualified researchers aged 21 and over.
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