Thymosin Alpha 1 RGDR
✓ Third-party tested by certified labs
✓ Published certificates of analysis
✓ ≥98.5% purity standard
Description
Thymosin Alpha 1-RGDR (Tα1-RGDR)
Tα1-RGDR combines the immunomodulatory properties of Thymosin Alpha 1 with tumor-targeting RGDR sequence through a flexible GGGG linker. This 36-amino acid modified peptide binds selectively to integrin αvβ3 and Neuropilin-1 (NRP-1) receptors overexpressed on tumor cells and vascular endothelium.
The RGDR motif contains both the RGD integrin-binding sequence and a C-terminal R/KXXR/K motif for NRP-1 recognition. Research in mouse models shows Tα1-RGDR targets tumor tissue more efficiently than unmodified Tα1 while maintaining immune system activation through CD4+ and CD8+ T cell upregulation.
Studies demonstrate applications in non-small cell lung cancer, melanoma, and other solid tumor models where integrin αvβ3 expression is elevated.
For in vitro research applications only.
Specification
| Specification | Details |
|---|---|
| Sequence | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Arg |
| Structure | Thymosin Alpha 1 (28 aa) + GGGG linker (4 aa) + RGDR targeting motif (4 aa) |
| Total Amino Acids | 36 amino acids |
| Molecular Formula | C167H279N49O67S (approximate) |
| Molecular Weight | ~3821 g/mol |
| Targeting Motifs | RGDR (integrin αvβ3 binding), C-terminal R/KXXR/K motif (NRP-1 binding) |
| Synonyms | Thymosin Alpha 1-RGDR, Tα1-RGDR, Modified Thymosin Alpha 1 |
| Purity | ≥99% (HPLC) |
| Solubility | Soluble in sterile water |
| Storage Conditions | Store at ≤-20°C, tightly sealed, away from heat and moisture |
| Physical Appearance | White lyophilized powder |
| Shelf Life | 36 months from date of manufacture when stored properly |
| Quality Verification | Third-party tested by certified laboratory |
| Manufacturing Standard | USA-made, pharmaceutical-grade, GMP compliant |
| Intended Application | In vitro research applications only |
