Description
PE-22-28 Spray delivers a short, potent analog of the natural peptide spadin in a ready-to-use intranasal format. Limitless Life Nootropics prepares each 20mg bottle in the USA.
What Is PE-22-28 Spray?
Spadin is a peptide released from the sortilin receptor that blocks TREK-1, a potassium channel involved in regulating neuronal excitability. Mice lacking TREK-1 show resistance to depression-like behavior, which made the channel a target of interest in mood research.
French researchers developed this compound as a shortened, seven-amino-acid version of spadin that retains its most active region. It was reported to inhibit TREK-1 with an IC50 of about 0.12 nM and, in mouse studies, produced antidepressant-like effects and increased hippocampal neurogenesis within days rather than weeks.
Each bottle contains 20mg in Premium or Non-Lyophilized grade.
Research Applications
Published preclinical work has examined this spray across several areas of investigation:
- TREK-1 potassium channel inhibition
- Depression-like behavior in mice
- Hippocampal neurogenesis
- Synaptogenesis markers
- Rapid-onset mood research models
Researchers can review peer-reviewed studies on spadin and TREK-1 through the National Library of Medicine (PubMed) database.
PE-22-28 Spray Specifications
| Product | PE-22-28 Spray |
|---|---|
| Compound type | Heptapeptide spadin analog |
| Available sizes | 20mg |
| Format | Pre-mixed research solution in a metered spray bottle |
| Purity | ≥99% (HPLC verified) |
| Origin | Manufactured in the USA |
| Testing | Independent third-party lab |
| Intended use | Laboratory research only |
The Limitless Life Nootropics Standard
Independent researchers, university groups and private laboratories rely on Limitless Life Nootropics for consistent quality and responsive service. Every listing includes accurate format and size information, our compounds are stored under controlled conditions until they ship, and we stand behind every order. If something is not right, our U.S.-based support team will make it right.
Quality and Third-Party Testing
Every batch of this spray sold by Limitless Life Nootropics is produced in the United States and verified by an independent third-party laboratory. Testing includes HPLC purity analysis and mass spectrometry identity confirmation, and a certificate of analysis is available for each lot so researchers can document exactly what they are working with.
Storage and Handling of PE-22-28 Spray
Store this spray cold (2–8°C) and away from light. Wipe the nozzle after each use and keep the bottle tightly closed to limit contamination and evaporation.
Documentation and Traceability
Every order of this spray is tied to a specific production lot, and lot details are recorded so that your team can trace materials back to their source. If you need documentation for a grant report, internal audit or publication methods section, our support team can provide the relevant lot information on request.
How Ordering Works
Orders placed with Limitless Life Nootropics are processed within one to two business days and ship from the United States in discreet, protective packaging. Temperature-sensitive items are packed to limit heat exposure in transit, and every order includes tracking so your lab knows exactly when materials will arrive. Secure checkout protects your payment details at every step.
Related Research Products
Teams working with this spray often explore Adalank Peptide Spray, Adamax / Adalank Spray Combo Pack (10mg/10mg) and Adamax Peptide Spray. Browse the full Cognitive Research collection, or view every compound in our research peptide catalog at Limitless Life Nootropics.
Frequently Asked Questions
What is spadin?
Spadin is a natural peptide derived from the sortilin receptor that blocks the TREK-1 potassium channel.
How much peptide is in the bottle?
Each bottle contains 20mg.
Is PE-22-28 Spray for human use?
No. It is sold strictly for laboratory research. It is not intended for human or animal consumption, diagnosis or treatment.
Where can I buy PE-22-28 Spray online?
You can order it directly from Limitless Life Nootropics, a U.S. supplier of third-party tested research peptides with fast, discreet shipping.
Research Use Only
All products sold by Limitless Life Nootropics are intended strictly for in-vitro laboratory research and scientific study. This product is not a drug, food, supplement or cosmetic, has not been evaluated by the FDA, and is not for human or veterinary use. Purchase is limited to qualified researchers aged 21 and over.
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